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Int. Rev. Allergol. Clin. Immunol. Family Med., 2017, XXIII/2: 060-063 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2017, XXIII/2: 060-063

Title: Elevated pentraxin 3 levels in intermittent allergic rhinitis both in and out of the pollen seas

Authors: Glück J, Rymarczyk B, Jura-Szołtys E, Rogala B. 

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02-02-2017

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN ENGLISH.

Elevated pentraxin 3 levels in intermittent allergic rhinitis both in and out of the pollen season


Glück J, Rymarczyk B, Jura-Szołtys E, Rogala B.

Chair and Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland

Int Rev Allergol Clin Immunol Family Med, 2017; Vol. 23, No. 2, 060

Allergic intermittent rhinitis has been proved to be of inflammatory origin with evidence of inflammatory state during pollen season. Pentraxin 3 is an acute-phase response protein with putative regulatory role in development of allergic inflammation.
The aim of the study
was to estimate if pentraxin 3 and two proinflammatory stimulators such as IL-1β and TNF-α levels in intermittent allergic rhinitis is different in and out of pollen season comparing to nonatopic subject, as well.
Material and methods
. Pentraxin 3 and IL-1β and TNF-α levels were measured in sera of patients with IAR in pollen season (IAR) and out of pollen season (IAR-out) and in healthy controls.
Results
. Significantly higher found levels of pentraxin 3 were found in intermittent allergic rhinitis subjects both in and out of pollen season as compared to controls (3.2 [1.6-9.2] vs. 3.6 [1.6-4.8] vs. 2.0 [1.3-2.54] ng/ml). Serum levels of pentraxin 3 significantly correlated with serum levels of both proinflammatory stimuli in IAR patients in pollen season.
Conclusions
. Elevated levels of pentraxin 3 both in and out-of pollen season suggest ongoing permanent minimal inflammation process in intermittent allergic rhinitis regardless of pollen exposure. Positive correlation between pentraxin 3 and IL-1β or TNF-α found only during pollen season indicates the role of these two proinflammatory cytokines in induction of allergic inflammation.

Key words: pentraxin 3, IL-1β, TNF-α, intermittent allergic rhinitis, pollen, inflammation