Int. Rev. Allergol. Clin. Immunol. Family Med., 2018, XXIV/3: 107-112 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2018, XXIV/3: 107-112

Title: Hyaluronic acid in knee osteoarthritis 

Authors: Michalski P, Baranowski P, Szymczak Z, Baranowska A, Płusa T, Dudek J. 

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Hyaluronic acid in knee osteoarthritis

Michalski P1, Baranowski P2, Szymczak Z1, Baranowska A2, Płusa T,3 Dudek J1.

Mazowian Rehabilitation Center „STOCER” Konstancin-Jeziorna, Poland; 1Subdepartment of Orthopedy; 2Department of Neuroothopedy; 3Medical Faculty of Łazarski University in Warsaw, Poland

Int Rev Allergol Clin Immunol Family Med, 2018; Vol. 24, No. 3, 107

More than half of patients with symptoms of osteoarthritis (OA) of the knee joint did not exceed 65 years of age, which is mainly associated with previous injuries. The therapeutic procedure is to reduce pain and improve the function of the joint. For this purpose, measures are taken to repair damaged interstitial cartilage, which are limited to intra-articular administration of biological preparations. One of them are preparations containing hyaluronic acid (HA), which being a component of the intercellular matrix improves its springiness and elasticity. In patients with symptoms of OA, the concentration of HA in the knee joint fluid is reduced, which gives the basis for the delivery of HA to improve the function of the joint. In vitro tests also reveal the anti-inflammatory effect of HA on cells and the slowing of apoptosis of chondrocytes in the course of OA by binding CD44 and ICAM-1 receptors, which are responsible for the cartilage matrix degradation process. The analgesic efficacy of HA administered together with the improvement of joint function has been demonstrated, which considerably delays decision making in total knee replacement. The use of total delivery of HA and platelet-rich plasma (PRP) in the OA regeneration process is beneficial and improves the quality of life of patients. The therapeutic effect results from the synergistic action of both biological substances.

Key words: osteoarthritis, hyaluronic acid, platelet-rich plasma