Pol. Merkur. Lek (Pol. Med. J.), 2018, XLV/268: 150-153 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2018, XLV/268: 150-153

Title: Assessment of serum selenium concentration in patients with autoimmune thyroiditis in Poznan district 

Authors: Szeliga A, Czyżyk A, Niedzielski P, Mleczek M, Maciejewski A, Dorszewska J, Łącka K. 

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Assessment of serum selenium concentration in patients with autoimmune thyroiditis in Poznan district

Szeliga A1, Czyżyk A2, Niedzielski P3, Mleczek M4, Maciejewski A5, Dorszewska J6, Łącka K5.

1Student Scientific Society, Medical University of Poznan, Poland; 2Department of Gynecological Endocrinology, Medical University of Poznan, Poland; 3Department of Analytical Chemistry, Adam Mickiewicz University in Poznan, Poland; 4Chair of Chemistry, Department of Wood Technology, University of the Nature, Poznan, Poland; 5Chair and Department of Endocrinology, Metabolism and Internal Medicine, Medical University of Poznan, Poland; 6Laboratory of Neurobiology, Department of Neurology, Medical University of Poznan, Poland

Autoimmune thyroiditis (AIT) is characterised by infiltration of lymphocytes and destruction of thyroid gland. It results from the interaction of genetic predisposition and environmental triggers. Among environmental factors some infections, medications and inadequate micronutrients supply like selenium (Se) deficiency are believed to play a role.
The aim of our study
was to assess the serum selenium concentration in patients with AIT and healthy volunteers in the Polish population living in the Poznan district, and to compare our results with similar trials conducted on other European AIT groups.
Materials and methods
. Fifty three patients with AIT were included in the study. Elevated thyroperoxidase antibodies and/or thyroglobulin antibodies concentration and abnormalities typical for AIT in the thyroid ultrasound were the inclusion criteria. A control group consisted of 36 healthy, age and sex-matched volunteers.
. The median Se concentration was 56.67 μg/L in the AIT group and 39.75 μg/L in the controls (p>0.05). Decreased Se concentration was observed in 62% of the patients and in 72% of the controls (p=0.47). There was no statistically significant difference in Se status in AIT group when compared to the other Polish, German, Austrian, Dutch and Greek populations with AIT. Significantly higher values were observed in Italian and Greek study when compared to present results in AIT group.
. No association between selenium status and prevalence of autoimmune thyroiditis in Polish population living in Poznan district was noticed. Nevertheless determination of the normal serum Se concentration for European populations is necessary. Further studies with enlarged studied groups should be implemented.

Key words: selenium, autoimmune thyroiditis, Hashimoto thyroiditis

Pol Med J, 2018; XLV (268); 150–153