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Pol. Merkur. Lek (Pol. Med. J.), 2018, XLV/270: 237-241 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2018, XLV/270: 237-241

Title: The number of intraepithelial lymphocytes in digestive tract in patients with IgG-dependent intolerance of cereal products 

Authors: Mędrek-Socha M, Błońska A, Konrad P, Pawłowicz M, Chojnacki J, Zieliński K, Chojnacki C. 

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

The number of intraepithelial lymphocytes in digestive tract in patients with IgG-dependent intolerance of cereal products


Mędrek-Socha M1, Błońska A1, Konrad P1, Pawłowicz M2, Chojnacki J2, Zieliński K,3 Chojnacki C1.

Medical University of Łódź, Poland: 1Department of Clinical Nutrition and Gastroenterological Diagnostics; 2Department of Gastroenterology; 3Department of Pathomorphology and Clinica Cytopathology

Abnormal reaction of food antigens cause a variety disorders of gastrointestinal tract. It is not clear why exactly the same products provoke diarrhea or constipation.
The aim of this study
was to assess the number of intraepithelial lymphocytes (IEL) in different parts of gastrointestinal tract in patients with specific IgG antibodies against wheat and secale products.
Material and methods
. The study was performed in 36 healthy subjects(group I) and in 70 patients with diarrhea predominant (group II, n=38) or with constipation (group III, n=32). The level of specific IgG antibodies in blood were determined using Food Detective tests (Cambridge Diagnostics). The biopsy material obtained from duodenum, jejunum as well as from right and left colon was used for routine hematoxylin-eosin staining.
Results
. In group II compared to control group the number of IEL was statistical higher in all part of gastrointestinal tract. Furthermore, in 9 patients (23.6%) in duodenum exceed 30/100 enterocytes, and in colon mucosa exceed 25/100 (21.0%) enterocytes. In patients with constipation (group III) the number of IEL was similar to healthy subjects.
Conclusion
. Food intolerance of cereal products may cause immuneinflammatory changes in digestive tract comparable to celiakia and lymphocytic colitis.

Key words: cereal products, IgG antibodies, food intolerance, intraepithelial lymphocytes

Pol Med J, 2018; XLV (270); 237–241