Int. Rev. Allergol. Clin. Immunol. Family Med., 2018, XXIV/4: 156-162 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2018, XXIV/4: 156-162

Title: Metformin and antiaging

Authors: Gutkowska K, Hirnle A, Tarka P, Nitsch-Osuch A. 

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Metformin and antiaging

Gutkowska K1, Hirnle A2, Tarka P1, Nitsch-Osuch A1.

1Department of Social Medicine and Public Health, Medical University of Warsaw, Poland; 2Student Scientific Group of the Chair and Department of Geriatrics, Medical University of

Int Rev Allergol Clin Immunol Family Med, 2018; Vol. 24, No. 4, 156

In the several past years intensive search for anti-wrinkle treatment has been conducted in order to discover various medicines, which improve health and extend life span. Metformin from biguanide belongs to oral hyperglycaemic medicines. For many years it has been one of the most popular medicinal substances applied in treating type 2 diabetes. Lately a significant development of scientific research has occurred which aims at identifying the effectiveness of metformin in other medical conditions apart from type 2 diabetes. In many cases, the effects proved to be favourable which resulted in expanding the therapeutic indications for applying the drug. The most important turned out to be the studies on the anticancer activity of metformin and its anti-aging potential. The drug affects directly the reduction of the ingested food and consequently decrease in the body mass. This is the result of direct metformin influence on hypothalamus regulating the feeling of satiety; it may also have an impact on metabolism and cell processes related to the development of chronic aging, including liver inflammation, fatty liver, oxidative damage, glycation, cell aging, decrease of autophagies, apoptosis and development of many types of cancer cells. The publication aims at investigating the role performed by metformin in the aging process.

Key words: metformin, aging processes, type 2 diabetes, antiaging