Newsletter

Pol. Merkur. Lek (Pol. Med. J.), 2019, XLVI/273: 130-133 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2019, XLVI/273: 130-133

Title: Influence of long-term steroid use on lymphocytes subsets in patients with lupus erythematosus 

Authors: Pełka K, Kłosowicz A, Wojas-Pelc A, Pastuszczak M. 

More details

06/273

40,00 zł

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN ENGLISH.

Influence of long-term steroid use on lymphocytes subsets in patients with lupus erythematosus


Pełka K, Kłosowicz A, Wojas-Pelc A, Pastuszczak M.

Department of Dermatology, Jagiellonian University, Collegium Medicum, Cracow, Poland

Glucocorticosteroids (GCS) were used for decades to modulate immune system. Numerous studies were performed to evaluate their effects on cell mediated response and humoral immunity.
The aim of study
was to evaluate the potential associations between chronic use of GCS and immunological tests.
Patients and methods
. A cohort of patients (n=15) from Department of Dermatology of University Hospital of Cracow, Poland with cutaneous lupus erythematous were identified on individual record review. Flow cytometry was performed to determine the counts of circulating subsets of lymphocytes. Additionally, using nephelometry, serum concentrations of immunoglobulins (i.e. IgA, IgM, IgG) were assessed.
Results
. Among 15 patients, 9 (60%) were receiving systemic GCS for at least one year prior to the study entry. Patients on long-term steroid use were found to have significantly lower counts of CD19+ cells when compared to those who were not treated with GCS. In a multivariate analysis, daily dose of GCS was found as an independent factor associated with lower number of CD19+ cells.
Conclusions
. Long-term GCS use seems to have the strongest impact on CD19+ cells. Further studies are needed to ascertain the clinical significance of this observation.

Key words: glucocorticosteroids, immune system, subpopulation of lymphocytes

Pol Med J, 2019; XLVI (273); 130–133