Newsletter

Pol. Merkur. Lek (Pol. Med. J.), 2019, XLVI/275: 209-212 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2019, XLVI/275: 209-212

Title: Mild hyperbilirubinemia as a marker of oesophageal varices in HCV-related compensated cirrhotic patients

Authors: Mikuła T, Suchacz MM, Stańczak W, Jabłońska J, Kozłowska J, Cybula A, Cianciara J, Wiercińska-Drapało A. 

More details

03/275

40,00 zł

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN ENGLISH.

Mild hyperbilirubinemia as a marker of oesophageal varices in HCV-related compensated cirrhotic patients

Mikuła T, Suchacz MM, Stańczak W, Jabłońska J, Kozłowska J, Cybula A, Cianciara J, Wiercińska-Drapało A.

Department of Infectious and Tropical Diseases and Hepatology, Medical University of Warsaw, Poland

The natural course of compensated liver cirrhosis caused by chronic hepatitis C virus (HCV) infection is still a very interesting problem in hepatology. The prognostic usefulness of the Child-Pugh and MELD score in compensated liver cirrhosis is still debated. Consequently, several attempts have been made to determine parameters other than included in the Child-Pugh score, which could be helpful in the prognosis of compensated liver cirrhosis assessment.
The aim of study
was to identify a clinical or laboratory markers correlated with higher risk of liver decompensation among HCVinfected patients with compensated liver cirrhosis and presence or absence of esophageal varices.
Material and methods
. The study included 176 HCV-infected patients with compensated liver cirrhosis (74 women and 102 men) registered in the Clinical Database of Patients with Liver Cirrhosis – e-Hepar. All patients were monitored during 252 weeks for the occurrence of liver failure symptoms and the development of hepatocellular carcinoma (HCC).
Results
. The presence of esophageal varices was significantly associated with total bilirubin ≥2.0 mg/dl, platelets ≤110.0 G/L and 6 points in Child-Pugh score (p<0.05). The cumulative 252 weeks incidence of clinical decompensation was higher in patients with varices in comparison to patients without them (p<0.05). Variceal hemorrhages were observed in 9 cases (23.1%). During the follow-up period 9 patients died due to HCC complications.
Conclusions
. Our findings underline the prognostic value of serum bilirubin (even mild elevation) and platelet count in HCV-infected patients with compensated liver cirrhosis. We have confirmed that liver decompensation is more frequent and more rapid in patients with compensated liver disease and concomitant oesophageal varices.

Key words: liver, compensated cirrhosis, HCV, oesophageal varices, hyperbilirubinemia

Pol Med J, 2019; XLVI (275); 209–212