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Int. Rev. Allergol. Clin. Immunol. Family Med., 2019, XXV/2: 049-052 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2019, XXV/2: 049-052

Title: The role of aquaporins in the inflammatory process 

Authors: Płusa T, Konieczny R, Baranowska J. 

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01-02-2019

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

The role of aquaporins in the inflammatory process


Płusa T1, Konieczny R2, Baranowska J2.

1Medical Faculty of Łazarski University, Warsaw, Poland; 2Department of Neurorthopedics, Mazovian Center of Rehabilitation „STOCER”, Konstancin-Jeziorna, Poland

International Review of Medical Practice, 2019; Vol. 25, No. 2, 049

Aquaporins constitute a group of 13 identified membrane proteins that form water channels that participate in the homeostasis process. Their expression is modulated depending on the physiological or pathological process, which can be used as a modern biomarker of inflammation. They affect the migration of T lymphocytes with simultaneous reduction of neutrophil and macrophage influx. The inflammatory domains observed in sepsis activate its activation and subsequent release of interleukin–1β, in which aquaporins actively participate in regulating the inflow of water into the cell. The turbulent changes observed in patients with sepsis in the form of acute lung injury, circulatory insufficiency, liver disorders and cerebral edema remain due to the disruption of aquaporins.

Key words: aquaporin, inflammation, biomarker