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Pol. Merkur. Lek (Pol. Med. J.), 2019, XLVII/280: 128-133 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2019, XLVII/280: 128-133

Title: Effects of the therapy combining calcium and vitamin D3 supplement with calcitonin on bone tissue density in patients with coronary heart disease complicated with chronic heart failure

Authors: Marushchak M, Krynytska I, Fedechko M, Sukhovolets I, Sydorenko O. 

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN ENGLISH.

Effects of the therapy combining calcium and vitamin D3 supplement with calcitonin on bone tissue density in patients with coronary heart disease complicated with chronic heart failure

Marushchak M1, Krynytska I1, Fedechko M2, Sukhovolets I3, Sydorenko O4.

1Department of Functional and Laboratory Diagnostics, I. Horbachevsky Ternopil National Medical University, Ukraine; 2Department of Family Medicine, Danylo Halytsky Lviv National Medical University, Ukraine; 3Department of Therapeutic Dentistry, I. Horbachevsky Ternopil National Medical University, Ukraine; 4Department of Urgent and Emergency Medical Care, I. Horbachevsky Ternopil National Medical University, Ukraine

As a long-term multisystem disorder, chronic heart failure (CHF) can gravely affect on bone metabolism, prompting a severe bone loss and increasing predisposition to fractures and the development of osteoporosis.
The aim of the study
was to investigate whether in patients with CHF a therapy combining calcium and vitamin D3 supplement (Calcemin Advance) and calcitonin (Miacalcic) can help to prevent and treat osteopenia and osteoporosis.
Material and methods
. Using dual-energy X-ray absorptiometry, we measured bone mineral density (BMD) in 59 patients with coronary heart disease (CHD) complicated with chronic heart failure.
Results
. Our results suggest that following the standard treatment protocol of CHD complicated with CHF resulted in significant BMD loss in the lumbar vertebrae, approaching the level of osteopenia. After taking a calcium and vitamin D3 supplement, patients with this heart disorder had significant increase of BMD in the lumbar vertebrae and in the femoral bone. Patients with CHD complicated with CHF and diagnosed osteoporosis taking Calcemin Advance did not experience osteoprotection outcome, rather their BMD continued to decrease. However, combined therapy with Miacalcic and Calcemin Advance was effective in significantly increasing L1, L2 – L4 BMD in these patients.
Conclusions
. We demonstrated effectiveness of using a calcium and vitamin D3 supplement, for patients with CHD complicated with CHF and diagnosed osteopenia. Patients with CHD complicated by CHF and diagnosed osteoporosis did not experience osteoprotective action when using Calcemin Advance. However, in these patients L1 lumbar vertebra BMD significantly increased after the combined therapy.

Key words: chronic heart failure, osteopenia, osteoporosis, treatment

Pol Med J, 2019; XLVII (280); 128–133