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Pol. Merkur. Lek (Pol. Med. J.), 2020, XLVIII/283: 005-009 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2020, XLVIII/283: 005-009

Title: Peculiarities of arterial hypertension in postmenopausal women with bone mineral density disorders and dyslipidemia 

Authors: Yarema N, Kotsiuba O, Krytskyy T, Marushchak M, Krynytska I.

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN ENGLISH.

Peculiarities of arterial hypertension in postmenopausal women with bone mineral density disorders and dyslipidemia


Yarema N1, Kotsiuba O2, Krytskyy T1, Marushchak M3, Krynytska I3.

I. Horbachevsky Ternopil National Medical University, Ukraine: 1Department of Internal Medicine No1; 2Department of Terapeutics and Family Medicine; 3Department of Functional and Laboratory Diagnostics

As a long-term multisystem disorders, cardiovascular diseases can gravely affect on bone metabolism, prompting a severe bone loss and increasing predisposition to fractures and the development of osteoporosis.
The aim of the study
was to analyze the peculiarities of bone mineral density (BMD), lipid spectrum, lipid peroxidation (LPO) and antioxidant system (AOS) activity in postmenopausal women with arterial hypertension (AH).
Material and methods
. Using dual-energy X-ray absorptiometry, we measured BMD in 193 women aged 45-62 years with the Stage II of AH. Lipid profile, LPO and AOS status in blood plasma were determined.
Results
. In postmenopausal patients with hypertension, BMD and T-score values are significantly lower in comparison with the women of control group without hypertension (by 11.3% (p<0.05) and 14.4% (p<0.05) respectively). Independent predictors of osteoporosis progression in women with AHare the duration of disease, as well as menopause onset and the duration of postmenopausal period. In postmenopausal patients with AH there is a correlation dependence between the atherogenicity index and menopause duration (r=0.40, p<0.01), as well as the inverse correlation dependence between the atherogenicity index and the age of menopause onset (r =-0.27, p<0.01), which suggests that the earlier menopause in women with AH occurs, the faster the atherogenicity of plasma lipids progresses. Postmenopausal patients with AH showed higher indices of lipoperoxidation processes and simultaneous lower indices of antioxidant defence.
Conclusions
. The bone mineral density in postmenopausal women with AH is significantly lower than in women of reproductive age. Independent predictors of osteoporosis progression in women with AH are the duration of disease, as well as menopause onset and the duration of postmenopausal period.

Key words: arterial hypertension, bone mineral density, menopause, lipids, peroxidation

Pol Med J, 2020; XLVIII (283); 005–009