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Int. Rev. Allergol. Clin. Immunol. Family Med., 2020, XXVI/1: 018-022 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2020, XXVI/1: 018-022

Title: Cytokines in the pathogenesis of chronic rhinosinusitis 

Authors: Wojdas A, Płusa T. 

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03-01-2020

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN ENGLISH.

Cytokines in the pathogenesis of chronic rhinosinusitis


Wojdas A1, Płusa T2.

1Department of Otolaryngology, Military Institute of Aviation Medicine, Warsaw, Poland; 2Medical Faculty of Lazarski University, Warsaw, Poland

International Review of Medical Practice, 2020; Vol. 26, No. 1, 018

Cytokines play an important role in host defense against microorganisms and are important in initiating, amplifying, directing, mediating, and regulating adaptive immunity. Evaluation of cytokine concentration may be an indicator of their stimulation or ability to respond to a specific stimulus. Disorders in the formation or function of cytokines directly affect the functioning of the immune system, which is not without significance for the formation and development of the disease. Cytokines in chronic rhinosinusitis play a key role in shaping the clinical picture of the disease, deciding its course, especially chronicity and complications. IL-1 is a cytokine that first appears in exudate in the course of nasal and sinusitis. The presence of IL-4R receptor in the mucosa of patients with chronic rhinosinusitis without nasal polyps has been demonstrated. The significant effect of IL-6 on the development of chronic sinusitis has been confirmed in several studies. Interleukin 25 participation in pathogenesis of chronic rhinosinusitis is little evidence and some connections with allergic reactions have been suggested. IL-33 is also observed as a potential mediator, however it is still somewhat controversial, in chronic rhinosinusitis. Recently it was documented that Th1-cytokines are mostly found in chronic rhinosinusitis without nasal polyps and Th2-cytokines in chronic rhinosinusitis with nasal polyps. But it is well known that several other cytokines have also been detected in both phenotypes of diasese.

Key words: cytokines, chronic rhinosinusitis, pathogenesis