Pol. Merkur. Lek (Pol. Med. J.), 2020, XLVIII/285: 162-165

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN ENGLISH.

Can the blood tryptase be an indicator of the severity of atopic dermatitis?

Jaworek AK1, Jaworek M2, Szafraniec K3, Pawlicka A4, Wojas-Pelc A1.

Jagiellonian University Medical College, Kraków, Poland: 1Department of Dermatology; 2Institute of Physiotherapy, Faculty of Health Sciences; 3Department of Epidemiology and Population Studies, Faculty of Health Sciences; 4Student Research Group of Dermatology

Atopic dermatitis (AD – atopic eczema) is a chronic inflammatory dermatosis resulting from complex genetic, epigenetic and environmental interactions with an overlapping defect in the epidermal barrier.AD is one of the most common inflammatory dermatoses in children and adults.
The aim of the study was to assess the relationship between serum basal tryptase (sBT) and total IgE (tIgE) level in blood serum and the severity of lesions (SCORAD; SCORing atopic dermatitis).
Material and methods. The study was performed in the group of adult patients (57 people, F/M: 30/27; average age: 37.5 years) and in the control group (10 people, K/M: 6/4; average age: 44 years). Diagnosis of atopic dermatitis was established by a dermatologist-allergist specialist based on the criteria of Hanifin and Rajka. The severity of lesions was determined on the SCORAD scale (SCORing atopic dermatitis).
Results. The distribution of tryptase concentration did not differ statistically significantly between patients with various disease severity and the control group also the severity of skin lesions was significantly higher (p <0.001) in patients whose tIgE level exceeded 3500 IU / ml.
Conclusion. sBT did not prove to be a useful biomarker in assessing severity of AD. The present study demonstrated that in the patients with atopic dermatitis the concentration of total IgE was correlated with severity of the disease symptoms.

Key words: atopic dermatitis, biomarkers, serum basal tryptase, total IgE, SCORAD

Pol Med J, 2020; XLVIII (285);162–165