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Int. Rev. Allergol. Clin. Immunol. Family Med., 2020, XXVI/2: 084-090 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2020, XXVI/2: 084-090

Title: Immunoglobulin concentrations in patients with chronic rhinosinusitis 

Author: Wojdas A. 

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05-02-2020

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Immunoglobulin concentrations in patients with chronic rhinosinusitis


Wojdas A.

Department of Otorynolaryngology, Military Institute of Aviation Medicine, Warsaw, Poland

International Review of Medical Practice, 2020; Vol. 26, No. 2, 084

MALT structures are referred to as the common immune system of the mucous membranes, which in the structures of the nasal cavity, paranasal sinuses and nasopharynx is referred to as NALT (nasopharynx-associated lymphoid tissue). NALT stimulation elicits an immune response initiated by antigen presentation and activation of B lymphocytes.
The aim of the study
was to compare the average total serum IgE and specific IgE concentration as well as the level of IgA, IgG and IgM antibodies in patients with CRS with and without atopy and to determine the severity of other symptoms of the disease.
Material and methods
. A total of 88 patients of both sexes, aged 18 to 69, divided into two groups of 44 people were qualified for the study. Group A are patients with CRS with accompanying atopy, and group B are patients with CRS without atopy. The control group consisted of 20 healthy people. In group A, the mean total IgE concentration in serum was significantly higher compared to the analogous values in group B (p <0.001) and in the control group (p <0.001). In group A, mean values of IgE specific for assessed allergens were significantly higher in relation to analogous values assessed in both other groups (p <0.001). In groups A and B, mean IgA concentration was statistically significant to the control group (p <0.001).
Conclusions
. The study showed that chronic rhinosinusitis in atopic and non-atopic patients causes a statistically significant (p <0.001) increase in the mean total IgA and IgE concentration as well as chronic rhinosinusitis in patients with atopy it causes a statistically significant (p <0.001) increase in the average concentration of specific IgE for specific aeroallergens.

Key words: NALT, immunoglobulins, chronic rhinosinusitis, atopy