International Review of Medical Practice, 2020, XXVI/2: 091-093 Maximize

International Review of Medical Practice, 2020, XXVI/2: 091-093

Title: Diagnostic difficulties in food anaphylaxis – a case report 

Authors: Cuprian D, Dżugaj N, Łątka F, Gomułka K. 

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Diagnostic difficulties in food anaphylaxis – a case report

Cuprian D, Dżugaj N, Łątka F, Gomułka K.

Department and Clinic of Internal Medicine, Pneumology and Allergology, Wroclaw Medical University, Poland

International Review of Medical Practice, 2020; Vol. 26, No. 2, 091

Anaphylaxis is a rapid, systemic reaction, which can lead to a patient’s death. In its mechanism, mediators of allergic reaction cause skin, breathing and gastrointestinal symptoms or they even lead to loss of consciousness or anaphylactic shock. As for genesis of food allergy, we sometimes have to take atypical correlations under consideration. The example is food-dependent exercise – induced anaphylaxis (FDEIA), which often means the same as diagnosing idiopathic anaphylaxis. Molecular diagnostics of allergy using the latest generation nanotechnology would be considerate help in such diagnostic difficulties.
Case report
. 38-year-old man, without history of chronic internal diseases, was admitted due to diagnostics of recurring mild food anaphylaxis incidents. In the process of allergic diagnostics concentrations of total IgE antibodies, complement component C3 and C4, C1-esterase inhibitor were checked – all of the results were normal. Pressure and thermal tests, as well as skin prick tests with food allergens, patch contact test and oral provocation test with acetylsalicylic acid were negative. Skin prick test with airborne allergens turned out to be positive for many allergens. Due to a multiplicity of factors that could cause the patient’s symptoms, oral provocation tests were abandoned. The planning of such tests would be possible only after receiving results of component-resolved diagnostics
: On the example of this patient, we would like to draw attention to possible difficulties in allergic diagnostics, such as: a multiplicity of oversensitivity causes, cross-reactivity, predisposing factors and patient’s subjective judgement. Moreover, our aim is also to emphasise an extremely helpful importance of componentresolved diagnostics.

Key words: anaphylaxis, food allergy, food-dependent exerciseinduced anaphylaxis, component-resolved diagnostics