Newsletter

International Review of Medical Practice, 2020, XXVI/4: 143-149 Maximize

International Review of Medical Practice, 2020, XXVI/4: 143-149

Title: Azithromycin in the prevention of exacerbations of eosinophilic and non-eosinophilic asthma

Author: Płusa T. 

More details

01-04-2020

40,00 zł

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Azithromycin in the prevention of exacerbations of eosinophilic and non-eosinophilic asthma

Płusa T.

The Faculty of Medicine of the Lazarski University in Warsaw, Poland

International Review of Medical Practice, 2020; Vol. 26, No. 4, 143

In line with the recommendations of GINA, in the fifth step of the treatment of a patient with bronchial asthma, add-on treatment should be considered in order to enhance the expected effect, expressed in a reduction the number of exacerbations and an improvement in the patients’ quality of life. In this aspect, attention was paid to the effectiveness of the second generation macrolide – azithromycin. It has been shown to have a modulating effect on the activity of macrophages and monocytes, as well as inhibition of the Th2 response and steroid-sparing effect. Moreover, the antiviral activity of the drug is disclosed, especially at higher doses. In the 2017 AMAZES study, 420 patients with asthma were administered 500 mg of azithromycin three times a week for 48 weeks, reducing the number of exacerbations and significantly improving the patients’ quality of life. In another analysis, which included Embase, MEDLINE, PubMed, Cochrane Library, ClinicalTrials.gov by February 2019, it was found that administration of azithromycin for at least 8 weeks reduced the number of exacerbations over a 6-month period, both in patients with eosinophilic asthma, non-eosinophilic and severe. However, it should be remembered that chronic administration of azithromycin in the prevention of exacerbations in patients with asthma is associated with the possibility of side effects.

Key words: azithromycin, bronchial asthma, exacerbations, prophylaxis