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Pol. Merkur. Lek (Pol. Med. J.), 2013, XXXIV/201: 158-160 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2013, XXXIV/201: 158-160

Title: Influence of nuclear factor-κB inhibition on –SH groups concentration in liver of rats

Authors: Michalski Ł., Kleniewska P., Piechota-Polańczyk A., Gorąca A.

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06/201

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Influence of nuclear factor-κB inhibition on –SH groups concentration in liver of rats


Michalski Ł., Kleniewska P., Piechota-Polańczyk A., Gorąca A.

Medical University of Lodz, Poland, Chair of Experimental and Clinical Physiology, Department of Cardiovascular Physiology

The aim of the study was to evaluate the influence of nuclear factor-κB inhibition on –SH groups concentration in liver of rat.
Material and methods
. Experiments were performed on Wistar-Kyoto rats divided into following groups: group I (control) received saline; group II (ET-1) received endothelin 1 (12.5 μg/kg b.w.); Group III (BAY 11-7082) received a nuclear factor-kappaB (NF-κB ) inhibitor (10 mg/kg b.w.); Group IV (BAY 11-7082+ET-1) received a nuclear factor-kappa B inhibitor (10 mg/kg b.w.) and 30 min later ET-1 (12.5 μg/kg b.w.).
Results
. Administration of endothelin 1 (ET-1) at a dose 12.5 μg/kg b.w. resulted in a statistically significant decrease in the concentration of –SH groups (p < 0.05 vs control). In contrast, BAY11-7082 (10 mg/kg b.w.) significantly increased the level of –SH groups in the liver in ET-1 induced oxidative stress (p < 0.02).
Conclusion
. A nuclear factor-kappa B inhibitor (BAY 11-7082) at a dose 10 mg/kg b.w. showed a significant increase in the concentration of –SH groups in the liver, in ET-1 induced oxidative stress.

Key words: endothelin 1, NF-κB inhibition, BAY 11-7082, oxidative stress

Pol. Merk. Lek., 2013, XXXIV, 201, 158