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Pol. Merkur. Lek (Pol. Med. J.), 2013, XXXIV/201: 175-178 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2013, XXXIV/201: 175-178

Title: Influence of chosen metals on the citric acid cycle 

Authors: Rojczyk-Gołębiewska E., Kucharzewski M.

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Influence of chosen metals on the citric acid cycle


Rojczyk-Gołębiewska E.1, Kucharzewski M.2

Medical University of Silesia in Katowice, Poland: 1Chair and Departament of Histology and Embriology; 2Chair and Department of Visual and Topographic Anatomy

Industrial activity growth influenced not only technological progress, but also had negative effects on human natural environment. It results among others in increased human exposition to heavy metals. In case of detoxication mechanisms disturbance in organism, heavy metals cumulate in tissues causing mutations and disrupting metabolism, including Krebs cycle. Recent studies have revealed that iron, zinc and manganese have especially strong influence on Krebs cycle. These elements act as cofactors or inhibitors regulating activity of particular enzymes of this cycle, which has a reflection in cellular energy production disturbances.

Key words: iron, zinc, manganese, Krebs cycle

Pol. Merk. Lek., 2013, XXXIV, 201, 175