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Pol. Merkur. Lek (Pol. Med. J.), 2014, XXXVII/218: 086-090 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2014, XXXVII/218: 086-090

Title: Assessment of anthropometric parameters and serum leptin and fetuin-A levels in children and adolescents with osteosarcoma after anticancer treatment

/ Authors: Ambroszkiewicz J., Rychłowska-Pruszyńska M., Chełchowska M., Rogowska E., Rowicka G., Klepacka T., Gajewska J.

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Assessment of anthropometric parameters and serum leptin and fetuin-A levels in children and adolescents with osteosarcoma after anticancer treatment


Ambroszkiewicz J.1, Rychłowska-Pruszyńska M.2, Chełchowska M.1, Rogowska E.2, Rowicka G.3, Klepacka T.4, Gajewska J.1

Institute of Mother and Child in Warsaw, Poland: 1Screening Department, 2Department of Oncological Surgery for Children and Youth, 3Department of Nutrition, 4Department of Pathomorphology

Cancer and the use of a comprehensive anti-cancer treatment are unfavorable factors, which have a significant impact on bone mass accumulation, bone mineralization and consequently the occurrence of osteoporosis. Bone turnover is regulated by complex mechanisms, among which an important role play OPG/RANK/RANKL signaling pathway, adipokines, and fetuin-A.
The aim of the study
was to evaluate bone mineral density and concentrations of leptin and fetuin-A in patients with osteosarcoma after anti-cancer treatment.
Materials and methods
. The study included 50 children and adolescents aged 10–21 years. The study group consisted of 25 patients with osteosarcoma and 25 healthy counterparts as a control group. The examination was conducted 2 months after the last course of postoperative chemotherapy and included densitometric measurements: bone mineral content (BMC), bone mineral density (BMD), fat mass, lean mass and biochemical measurements: serum concentrations of calcium, magnesium, phosphate, 25-hydroksyvitamin D, alkaline phosphatase, leptin and fetuin-A. Concentrations of leptin and fetuin-A were determined by immunoenzymatic methods.
Results
. In patients with osteosarcoma after anti-cancer treatment, we observed significantly reduced bone mineral content, bone mineral density and lean body mass compared with the healthy children (p
Conclusion. The deficit in bone mass observed in patients with malignant bone tumors after anti-cancer treatment might be the result of decreased serum calcium and vitamin D concentrations. The observed correlation between anthropometric and biochemical parameters may indicate the link between bone and adipose tissue metabolism.

Key words: bone mineral density, leptin, fetuin-A, osteosarcoma

Pol. Merk. Lek., 2014, XXXVII, 218, 86