Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXIII/198: 346-348

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

The role of paracetamol in transition reactions of alpha-nitrogen and oxidative stress in the liver

Polaniak R.1, Bułdak R.J.2, Birkner E.1, Karbowska D.1, Ochocki K.1, Szkilnik R.3

Silesian Medical University of Katowice, Poland: 1Department of General Biochemistry, The Chair of Biochemistry in Zabrze; 2Chair and Department of Physiology in Zabrze; 3Chair and Department of Basic Medical Sciences, Public Health Faculty in Bytom

Paracetamol (Acetaminophen, PC) is metabolized in liver to N-acetylp- benzoquinon-imine (NAPQI), that is in turn conjugated by glutathione S-transferase with glutathione. NAPQI inhibits the respiratory chain. It may cause a 90% decrease of ATP concentration in mitochondria of hepatocytes. The oxidation of paracetamol to quinine form can also generate free radicals. Both above mentioned processes, can injure the mitochondria and cells. There have not been found in accessible literature any data dealing with paracetamol influence on the process elimination of the alpha nitrogen in the liver. The ATP concentration decline may lead to disturbances in mitochondrial enzymes. There are discrepant data of the role of free radicals in the mechanism of toxic action of paracetamol.

Key words: paracetamol, alpha-nitrogen, antioxidative enymes, free radicals

Pol. Merk. Lek., 2012, XXXIII, 198, 346