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Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXIII/198: 364-369 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXIII/198: 364-369

Title: Anticancer activity of flavonoids

Authors: Majewska-Wierzbicka M., Czeczot H.

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Anticancer activity of flavonoids


Majewska-Wierzbicka M., Czeczot H.

Medical University of Warsaw, Poland, Chair and Department of Biochemistry, First Faculty of Medicine

On the basis of previous in vitro, in vivo and epidemiological studies was found that flavonoids among their many biological and pharmacological properties have a great anticancer potential. High intake of foods rich in these compounds, mainly vegetables and fruits is associated with a low rate of cancer in humans. Flavonoids may act at different stages of carcinogenesis: initiation, promotion and progression. The complex mechanism of antitumor action include: antioxidant activity, carcinogens inactivation, antiproliferation, block of the cell cycle, induction of apoptosis and differentiation, inhibition of angiogenesis and elimination of drug resistance. With multidirectional action in carcinogenesis and targeting its action only on cancer cells, it is suggested that these compounds may give a new perspective of their use in prevention and therapy of cancer.

Key words: flavonoids, anticancer activity, in vitro and in vivo studies

Pol. Merk. Lek., 2012, XXXIII, 198, 364