Newsletter

Pol. Merkur. Lek (Pol. Med. J.), 2011, XXXI/182: 092-096 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2011, XXXI/182: 092-096

Title: Evaluation of the influence of tianeptine on the psychosomatic status of patients with ulcerative colitis in remission

Authors: Chojnacki C., Walecka-Kapica E., Klupińska G., Pawłowicz M., Florkowski A., Wachowska-Kelly P., Chojnacki J.

More details

04/182

40,00 zł

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Evaluation of the influence of tianeptine on the psychosomatic status of patients with ulcerative colitis in remission


Chojnacki C.1, Walecka-Kapica E.2, Klupińska G.2, Pawłowicz M.1, Florkowski A.3, Wachowska-Kelly P.1, Chojnacki J.1

Medical University of Lodz, Poland: 1Department of Gastroenterology; 2Department of Clinical Nutrition; 3Department of Psychiatry for Adults

In order to maintain ulcerative colitis (UC) in remission, chronic use of aminosalicylates is recommended. All patients have a fear of the recurrence of symptoms, which makes their mental state and quality of life worse. Because of this a number of patients are recommended to use different sorts of anxiolytic drugs and antidepressants.
Aim of the study
was evaluation of the influence of tianeptine (selective serotonin reuptake enhancer) on the mental and somatic status in the group of patients.
Material and method
. The research was conducted in two groups of thirty patients, with benign form of ulcerative colitis in remission, aged 24-46 years. Patients, during a period of 12 months, were given aminosalicylates in a daily doses 2 × 1.0 g and tianeptine in a doses 3 × 12.5 mg (group I) or placebo (group II). During the treatment every three months anxiety (Hamilton Anxiety Rating Scale – HARS), depression (Back Depression Inventory - BDI), The Mayo Clinic Disease Activity Index (MCDAI), hemoglobin and C-reactive protein (CRP) level were evaluated.
Results
. After 12 months in a group of patients who took tianeptine decrease in anxiety (from 20.35 ± 4.03 to 12.65 ± 3.78 points) and depression (from 19.95 ± 4.49 points to 9.60 ± 2.76 points) was obtained; difference compared with placebo was statistically significant (p < 0.01). At the same time significant decrease compared with placebo (p < 0.05) of disease activity index (respectively 3.05 ± 1.36 and 4.65 ± 1.69), insignificantly lower level of CRP (7.00 ± 5.65 and 9.41 ± 10.12) and higher level of hemoglobin (11.93 ± 0.83 and 11.0 ± 0.70) was observed.
Conclusions
. Tianeptine has a positive influence on mental and somatic status of patients with UC. Results give the support for tianeptine apllication in UC as adjuvant drug.

Key words: tianeptine, ulcerative colitis, activity index, emotional state

Pol. Merk. Lek., 2011, XXXI, 182, 92