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Int. Rev. Allergol. Clin. Immunol. Family Med., 2015, XXI/1: 012-016 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2015, XXI/1: 012-016

Title: The impact of genetic polymorphism of 781C/T in the gene encoding IL-8 on the general risk for chronic obstructive pulmonary disease 

Authors: Rubinsztajn R, Gąsior G, Przybyłowski T, Karwat K, Maskey-Warzęchowska M, Pierzchała W, Mazurek U, Chazan R 

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02-01-2015

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH. 

The impact of genetic polymorphism of 781C/T in the gene encoding IL-8 on the general risk for chronic obstructive pulmonary disease

Rubinsztajn R1, Gąsior G2, Przybyłowski T1, Karwat K1, Maskey-Warzęchowska M1, Pierzchała W2, Mazurek U3, Chazan R1.

1Department of Internal Medicine, Pneumonology and Allergology, Medical University of Warsaw, Poland; 2Department of Pneumonology, Medical University of Silesia in Katowice, Poland; 3Chair with the Department of Molecular Biology, Medical University of Silesia in Katowice, Poland

Int. Rev. Allergol. Clin. Immunol. Family Med., 2015; Vol. 21, No. 1, 12

Genetic predisposition is considered to be one of the factors increasing the risk of chronic obstructive pulmonary disease (COPD). The best known is alpha-1 antitrypsin deficiency, which is a genetic factor responsible for emphysema.
The aim of the study
was to assess the effect of genetic polymorphism 781 C/T in the gene encoding IL-8 on the risk for COPD.
Material and methods
. The study group consisted of 162 patients (53 female, 109 male), at the age of 69.8±8.5 years, represanting all stages of COPD severity according to GOLD 2010 classification criteria (in stage 1 – 16 patients, in stage 2 – 71 patients, in stage 3 – 41 patients, in stage 4 – 34 patients) and 100 healthy volunteers. The spirometry, body plethysmography, 6 minute walking test (6MWT) and assessment of molecular polymorphism of 781C/T in the gene encoding IL-8 were performed in all patients.
Results
. There were no significant differences in the prevalence of 781 C/T IL-8 gene polymorphism in COPD patients vs control group (CC 38% vs 29%; CT 44% vs 55%, TT 18% vs 16%) and between COPD patients stratified according to the GOLD 2010 classification (GOLD 1: CC 37.5%, CT56, 3%, TT 6.2%; GOLD 2: CC 40,9%, 22.5% CT, TT 36.6%; GOLD 3: CC 39%; CT 53.7%, TT 7.3%; GOLD 4 CC 32,3%, CT 41,2%, TT 32.5%). In the group of patients older > 65 years, T homozygotes demonstrated significantly lower FEV1 and a shorter 6MWT distance. In T homozygote group as a whole, the highest number of comorbidities per person was found.
Conclusions
. The incidence of different polymorphisms of 781 C/T gene encoding IL-8 in patients with COPD is not different from the control group. COPD homozygotes T over the age of 65 years demonstrate a statistically lower FEV1 and worse exercise performance. It seems that this group may have a worse prognosis caused by accelerated the natural FEV1 decline.

Key words: polymorphism 781 C/T, COPD, IL-8