Int. Rev. Allergol. Clin. Immunol. Family Med., 2015, XXI/3: 105-108

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

The importance of exogenous factors in the etiology of sarcoidosis

Chełstowska S1, Płusa T.2

Military Institute of Medcine in Warsaw, Central Clinical Hospital of the Ministry of National Defense: 1Department of Hematology; 2Department of Internal Medicine, Pulmonology and Allergology

Int. Rev. Allergol. Clin. Immunol. Family Med., 2015; Vol. 21, No. 3, 105

Despite numerous research on the pathogenesis of sarcoidosis still has not been defined a factor responsible for triggering an immune response that leads to the development of a full picture of the disease. Raised part of progenitor cells, in addition to numerous non-specific factors, requires further research and clinical assessments. Similarly, conditional mutual sarcoidosis and tuberculosis, has not been fully confirmed. Participation in these reactions of heat shock proteins indicates the real possibility of the coexistence of changes in the inflammatory process. Interesting seems to be the role of vitamin D, because its deficiency can cause inadequate regulation of activated T cells and delay the removal of bacterial antigens from the body.

Key words: sarcoidosis, vitamin D, infectious agents