Int. Rev. Allergol. Clin. Immunol. Family Med., 2015, XXI/3: 115-121 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2015, XXI/3: 115-121

Title: The influence of platelet-rich plasma on the initial symptoms of knee osteoarthritis

Authors: Krześniak A, Płomiński J, Anielski R. 

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The influence of platelet-rich plasma on the initial symptoms of knee osteoarthritis

Krześniak A, Płomiński J, Anielski R.

Military Institute of Medicine in Warsaw, Central Clinical Hospital of the Ministry of National Defense, Department of Orthopaedics

Int. Rev. Allergol. Clin. Immunol. Family Med., 2015; Vol. 21, No. 3, 115

Osteoarthritis of the knee is a common cause of impairment of its function. Its first symptom is an articular cartilage damage. In recent years, much attention was paid to research the possibilities of biological cartilage repair. One of the most developed methods is the treatment of platelet-rich plasma (PRP), where the presence of growth factors and cytokines determines its anti-inflammatory and regenerative activity.
The aim of the study
is to evaluate the efficacy of platelet-rich plasma in patients with symptoms of knee osteoarthritis and to characterize groups of patients who are most likely to improve after treatment.
Material and methods
. The study included 40 patients with osteoarthritis of the knee between the ages of 18-81. Clinical examination confirmed pain in their knees. On the basis of the classical radiographs the severity of degenerative changes according to Kellgren-Lawrence scale was evaluated. Patients were given a single injection of standardized PRP in the knee joint. Evaluation of the results was carried out using a subjective assessment of the knee questionnaire before the injection and after 6 weeks. The results were correlated with gender, age, body mass index, the cause of symptoms and the severity of osteoarthritis.
. Comparison of the mean score of the questionnaire of the whole study group before the injection of PRP to the score after the injection occurred to be statistically significant at p<0.05. Similarly, the differences between the results of both women and men or of patients with a history of trauma and without trauma showed statistical significance. There was no significant difference in the relationship between the measurements before and after injection and the grouping variables (age, cause of osteoarthritis, BMI, severity of osteoarthritis according to Kellgren-Lawrence scale).
. It is not possible to identify groups of patients whose reaction on the treatment with PRP is different compared to other groups of patients. However, regardless of age, gender, body mass index, severity of degenerative changes and the presence of injury in the past, PRP significantly reduces pain and improves joint function affecting the increase of patient’s activity.

Key words: platelet-rich plasma, knee osteoarthritis, cartilage damage, growth factors