Newsletter

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/1: 007-013 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/1: 007-013

Title: The significance of the central and peripheral nervous system in the control of cough

/ Authors: Płusa T.

More details

01-01-2014

40,00 zł

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

The significance of the central and peripheral nervous system in the control of cough

Płusa T.


Military Institute of Medicine in Warsaw, Poland, Central Clinical Hospital of the Ministry of National Defense, Department of Internal Medicine, Pneumonology and Allergology

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014; Vol. 20, No. 1, 007

Antitussive drugs acting on the central and peripheral nervous system are able to reduce the frequency and intensity of coughing. Potential causes of cough induced by changes in the upper airway are allergic reactions and neuromotoric mechanisms, but also the ongoing inflammation in the sinuses and throat. In the course of chronic respiratory diseases may occur to mechanical damage receptors responsible for inducing cough. Cough as a defensive reflex is triggered by tracheobronchial receptors to fast adopters (RARs – adapting rapidly receptors). Opioid receptors exert their suppressive efficacy on cough reflex after administration of codeine. GABA (γ- aminobutyric acid) disclose suppressive effect on cough mechanism by acting on the structure in the brain stem. In turn, serotonin receptors (5-HT – 5 hydoxytryptamina) are involved in triggering the cough reflex, but serotonin receptor agonists and 5- HT1A receptors are able to inhibit cough. Also the sigma and tachykinin receptors are involved in the induction of cough, as well as irritant receptors referred to as TRP (transient receptor potential). Among the “suppressants” cough center of the action lists, among others, morphine, pholcodine, baclofen. Currently, the treatment of dry coughs exhausting recommended central acting drugs which are not addictive and do not exhibit potent effects on the respiratory center, including registered in Poland dextromethorphan and citrate butamirate. Also antyhistaminics and phosphodiesterase inhibitors have antitussive activity.

Key words: cough, brainstem, cough receptors