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Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/1: 014-018 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/1: 014-018

Title: Atypical lymphocytes morphology: an adverse prognostic factor associated with CD38 expression on chronic lymphocytic leukemia cells

/ Authors: Chełstowska S., Wajs J., Krystek A., Drozd E., Rzepecki P.

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02-01-2014

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Atypical lymphocytes morphology: an adverse prognostic factor associated with CD38 expression on chronic lymphocytic leukemia cells

Chełstowska S., Wajs J., Krystek A., Drozd E., Rzepecki P.

Military Institute of Medicine in Warsaw, Poland, Central Clinical Hospital of the Ministry of National Defense, Department of Hematology with Bone Marrow Transplantation Ward

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014; Vol. 20, No. 1, 014

The aim of the study was to investigate the incidence of atypical lymphocytes in patients with CD38 positive and CD38 negative type of chronic lymphocytic leukemia (CLL).
Material and methods
. Cell morphology we evaluated using French-American-British Group (FAB) criteria. In addition, we used basic planimetric parameters of cells and cells nuclei. In this way, we objectively and clearly made a distinction between typical and atypical forms of lymphocytes, to obtain for most evaluated features statistically significant differences.
Results
. Morphologically atypical CLL occurred more frequently in CD38+ patients (93%) than in CD38- patients (20%).

Key words: chronic lymphocytic leukemia, prognostic factors, atypical lymphocytes morphology, CD38 antigen