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Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/1: 019-022 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/1: 019-022

Title: Chronic infection of Mycoplasma pneumoniae and Chlamydophila pneumoniae in patients with sarcoidosis

/ Authors: Wesołowski A., Targowski T., Rożyńska R.

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03-01-2014

40,00 zł

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Chronic infection of Mycoplasma pneumoniae and Chlamydophila pneumoniae in patients with sarcoidosis

Wesołowski A., Targowski T., Rożyńska R.


Military Institute of Medicine in Warsaw, Poland, Central Clinical Hospital of the Ministry of National Defense, Department of Internal Medicine, Pneumonology and Allergology

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014; Vol. 20, No. 1, 019

Chronic post infection inflammation may cause or exacerbate interstitial lung diseases.
The aim
of this study was to find connection between atypical pathogens infections and sarcoidosis.
Material and methods.
The study group consisted of 27 patients with pulmonary sarcoidosis (grade III). They were not treated with corticosteroids for at least last six months. 22 persons were the control group. At every patient bronchoscopy and bronchioalveolar lavage was performed. Obtained fluid was subjected to the morphological and PCR examination for presence of the genetic material of atypical pathogens. Positive titres of antibodies against atypical patogens, cellularity of BAL fluid (BALF), and relationship between antibodies' titres and BALF cellularity were compared.
Results
. At none of examined with PCR method the presence of a Mycoplasma pneumoniae or Chlamydophila pneumoniae DNA sample wasn't stated in liquid from the bronchoalveolar lavage. There were no statistically significant differences concerning cellular elements in a liquid from the bronchoalveolar lavage depending on the presence of IgG, IgM and IgA antibodies against Mycoplasma pneumoniae and Chlamydophila pneumoniae in the studied groups, as well as differences in the percentage of participants with positive antibody titer against atypical pathogens in the both groups.
Conclusions
. At almost everyone examined serologic evidence for infection or the contact with Mycoplasma pneumoniae was detected, what is providing about big spreading this pathogen in our environment. There were no significant differences in the percentage of people with positive atypical antibodies titre between study and control groups, and substantial morphological differences of BALF in relation to serologic evidence of infection or contact with Mycoplasma or the Chlamydophila. It seems, that detecting of genetic material of Chlamydophila pneumoniae or Mycoplasma pneumoniae in the BALF in patients without symptoms of acute respiratory infection is clinically useless.

Key words: atypical infections, Mycoplasma, Chlamydophila, chronic inflammation, BAL