Newsletter

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/1: 035-041 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/1: 035-041

Title: The possibility of high resolution computed tomography in the evaluation of inflammatory and structural changes in patients with bronchial asthma

/ Authors: Omernik A., Płusa T.

More details

06-01-2014

40,00 zł

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

The possibility of high resolution computed tomography in the evaluation of inflammatory and structural changes in patients with bronchial asthma

Omernik A., Płusa T.


Military Institute of Medicine in Warsaw, Central Clinical Hospital of the Ministry of National Defence, Department of Internal Medicine, Pneumonology and Allergology

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014; Vol. 20, No. 1, 035

Inflammation of the airways in patients with asthma is present throughout the bronchial tree. The variety of clinical images indicates that patients may vary in location of the peak of inflammation. Increasingly, the role of inflammation is raised in small bronchi having a diameter of less than 2 mm. It is postulated that the presence of even small bronchitis phenotype, so the group of patients with an inflammation of the small airways is responsible for the clinical picture of the disease. Due to the differences in the deposition of inhaled drugs used at different levels of the bronchial tree are sought methods to evaluate the severity of inflammatory processes in the different generations of bronchi. Bronchoscopic examination allows assessment of changes in large and medium-sized bronchi, without the possibility of penetration of their peripheral parts. In turn the sputum, nitric oxide concentration in exhaled air, exhaled breath condensate, and determining the concentration of serum C-reactive protein, eosinophil cationic protein, do not allow for an indication of ongoing inflammation in the proper selection of therapy. One promising method is to measure the wall thickness of bronchial with the high resolution computed tomography that enables imaging of the bronchial even less than 2 mm. It has been shown the existence of a bronchial wall thickness (WT – wall thickness) with inflammation identified in biopsy material, the degree of asthma control and severity of the disease. Relationship with the results of functional studies is not clear. The method is used to assess the effectiveness of therapy. The possibility of imaging the small bronchi should lead to its use in determining the group of patients who will benefit from the use of drugs with the fine formulation.

Key words: asthma, high-resolution computed tomography, small bronchi, inflammation