Pol. Merkur. Lek (Pol. Med. J.), 2016, XL/235: 032-035 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2016, XL/235: 032-035

Title: The role of reactive oxygen species (ROS) in arrhythmogenesis 

Authors: Tytman K, Kaczmarek K, Lipińska S, Wranicz JK.

More details


40,00 zł


The role of reactive oxygen species (ROS) in arrhythmogenesis

Tytman K1, Kaczmarek K1, Lipińska S2, Wranicz JK1.

Medical University of Lodz, Poland: 1Department of Electrocardiology; 2Department of General Physiology

Reactive oxygen species (ROS) are the molecular oxygen derivatives that have at least one unpaired electron. Thus, ROS easily react with a number of cell structures causing a change in their functions. ROS produced in small quantities positively affect many cellular mechanisms, but in excess are responsible for the formation of oxidative stress. Oxidative stress is considered a major cause of many diseases, including cardiovascular disease. Abolition of the adverse effects of ROS on organisms in order to maintain redox homeostasis is possible thanks to antioxidants. The research conducted mainly in recent years shows that the formation of arrhythmias may also be related to the phenomenon of oxidative stress. Oxidative damage to cell membranes in particular are causing changes in ion channel activity, which proper functioning is the basis for the formation of normal heart rhythm. Antioxidants seem to play a protective role against the formation of arrhythmias.

Key words: free radicals, oxidative stress, ventricular tachycardia

Pol Med J, 2016; XL (235); 32–35