Pol. Merkur. Lek (Pol. Med. J.), 2016, XLI/242: 101-106 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2016, XLI/242: 101-106

Title: Cardiac sarcoidosis – clinical manifestation and diagnosis 

Authors: Błaut-Jurkowska J, Podolec P, Olszowska M. 

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Cardiac sarcoidosis – clinical manifestation and diagnosis

Błaut-Jurkowska J, Podolec P, Olszowska M.

Department of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, Cracow, Poland

Sarcoidosis is a multisystem inflammatory disease defined histologically by the formation of noncaseating granulomas. The etiology of sarcoidosis remains unknown. Heart involvement in the course of sarcoidosis concerns about 5% of patients. The most common manifestation of cardiac sarcoidosis are conduction abnormalities, arrhythmias and heart failure. The diagnostic algorithm includes performing a clinical history, a 12-lead electrocardiogram (ECG) and an echocardiogram. If any of the initial screening investigations yields an abnormality, diagnostics should be continue using advanced imaging techniques: cardiovascular magnetic resonance (CMR) or fluorodeoxyglucose positron emission tomography (FDG-PET). Nowadays endomyocardial biopsy is not performed routinely.The clinical picture of cardiac sarcoidosis is highly variable. Screening for cardiac sarcoidosis should be performed in all patients diagnosed with extracardiac sarcoidosis. Cardiac sarcoidosis should also be suspected in young patients without a diagnosis of sarcoidosis who present with conduction abnormalities of unknown etiology, because cardiac sarcoidosis may be the first or the only manifestation of the disease.

Key words: sarcoidosis, cardiac sarcoidosis, clinical manifestation, symptoms, signs, diagnosis, diagnostic criteria

Pol Med J, 2016; XLI (242); 101–106