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Pol. Merkur. Lek (Pol. Med. J.), 2016, XLI/244: 188-191 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2016, XLI/244: 188-191

Title: Safety of use of micronized diosmin at daily doses up to 2000 mg per day 

Author: Staniewska A. 

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Safety of use of micronized diosmin at daily doses up to 2000 mg per day

Staniewska A.

Specialist Medical Practice DAGDERM in Warsaw

Formulations of micronized diosmin (MPFF) are widely used in the treatment of chronic venous disease, hemorrhoidal disease and other indications. The usual recommended dose of micronized diosmin is 1000 mg once daily. Numerous studies confirm the superior efficacy and safety of higher doses of diosmin up to 2000 mg per day in a few months therapy.
The aim of the study
was to observe the efficacy and safety of micronized diosmine used in a daily dose of 1000 and 2000 mg for 4 months.
Material and methods
. The study involved 327 patients meeting the inclusion and exclusion criteria. The parameters were measured immediately prior to the first dose and at 2 and 4 months of therapy. The safety analysis was conducted and the results obtained from measured parameters are presented in tables.
Results
. No significant abnormalities in the following parameters were observed: complete blood cell count, fibrinogen level, the level of alanine transaminase and aspartate, the level of urea and creatinine, urinalysis. The therapy did not affect the level of systolic and diastolic blood pressure. There was no significant adverse events in the study groups.
Conclusions
. Cited in this publication results of a clinical study support the use of micronized diosmin at doses up to 2000 mg per day.

Key words: Diosmin, venous insufficiency, safety therapy.

Pol Med J, 2016; XLI (244); 188–191