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International Review of Medical Practice, 2020, XXVI/3: 118-122 Maximize

International Review of Medical Practice, 2020, XXVI/3: 118-122

Title: Treatment of infections with bacteriophages in orthopedics 

Authors: Płusa T, Konieczny R, Baranowski P. 

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03-03-2020

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Treatment of infections with bacteriophages in orthopedics


Płusa T1, Konieczny R2, Baranowski P2. 1Medical Faculty of Lazarski University, Warsaw, Poland; 2Department of Neuroorthopedics of Mazovian Rehabilitation Center in Konstancin-Jeziorna, Poland

International Review of Medical Practice, 2020; Vol. 26, No. 3, 118

Treatment with bacteriophages has been over 100 years. After the first promising experiences in the treatment of traumatic infections on the battlefield, interest in this therapy was lost because of the emergence of antibiotics. In view of the growing resistance of bacteria to the antibiotics used, experimental and clinical research on bacteriophages was resumed. However, the most promising results are the results of studies on the simultaneous administration of antibiotics and bacteriophages in infections caused by Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas aeruginosa. The obtained results indicate the synergism of action, which enables the administration of antibiotics at sub-minimal concentrations. Moreover, the disclosed effect of combination therapy in controlling biofilm formation, especially in orthopedic surgery, points to new therapeutic possibilities.

Key words: bacteriophages, antibiotics, infections, orthopedic surgery