International Review of Medical Practice, 2020, XXVI/4: 162-165 Maximize

International Review of Medical Practice, 2020, XXVI/4: 162-165

Title: The effect of nitric oxide on bone metabolism 

Authors: Wolszczak-Biedrzycka B, Bieńkowska-Iwanik A, Biedrzycki G, Kloc W. 

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The effect of nitric oxide on bone metabolism

Wolszczak-Biedrzycka B1, Bieńkowska-Iwanik A1, Biedrzycki G2, Kloc W1.

1Department of Public Health, Collegium Medicum, University of Warmia Mazury in Olsztyn; 2Hospital Pharmacy, Provincial Specialist Hospital

International Review of Medical Practice, 2020; Vol. 26, No. 4

Nitric oxide (NO) is one of many factors responsible for the process of bone reconstruction in both health and disease. NO synthases occurring in the form of three isoforms are present in bone marrow, fetal cells, osteoblasts, osteocytes, osteoclasts (eNOS), bone lining cells and osteocytes (nNOS) and fetal bones (iNOS). There is good evidence to suggest that NO has a biphasic resorption effect through osteoclasts. It has been shown that low NO concentration increases bone resorption induced by IL-6, while increased NO concentration inhibits the formation and activity of osteoclasts. NO also has a biphasic effect on osteoblast activity. In vitro studies have shown that even a small amount of NO, which is produced by osteoblasts, can act as a stimulus for osteoblast growth and cytokine production. High concentrations of NO, such as those observed after stimulation by pro-inflammatory cytokines, have an inhibitory effect on the growth and differentiation of osteoblasts. Recent evidence suggests that this may be partly due to the pro-apoptotic effects of NO on osteoblasts.

Key words: nitric oxide, bone metabolism, osteoblasts, osteoclasts