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Pol. Merkur. Lek (Pol. Med. J.), 2013, XXXV/205: 018-021 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2013, XXXV/205: 018-021

Title: Assessment of concentrations of A, C and E vitamins in the plasma of patients with NSCLC undergoing first-line chemotherapy 

Authors: Tokarski S., Rutkowski M., Mejer A., Godala M., Kowalski J.

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Assessment of concentrations of A, C and E vitamins in the plasma of patients with NSCLC undergoing first-line chemotherapy


Tokarski S.1, Rutkowski M.2, Mejer A.3, Godala M.4, Kowalski J.3

1Hospital of Lung Diseases and Tuberculosis in Rzeszów, Poland, Department of Lung Diseases and Tuberculosis; Medical University of Łódź, Poland: 2Department of Military Toxicology and Radiological Protection; 3Department of Internal Diseases and Cardiologic Rehabilitation; 4Hygiene of Nutrition and Epidemiology Department

Lung cancer is one of the most common cancer types and it usually takes the form of non-small cell lung cancer (NSCLC). ROS take part in the process of carcinogenesis. What more, chemotherapy used in cancer treatment augments their production, leading to the weakening of the antioxidative barrier. As a result in cancer patients undergoing chemotherapy the reduction-oxidation processes are imbalanced. Vitamins A, C and E form an important part of the nonenzymatic antioxidative barrier in humans.
The aim of the study
was an assessment of concentrations of A, C and E vitamins in the plasma of patients with NSCLC before and after chemotherapy.
Material and methods
. 25 first-line chemotherapy patients with inoperable NSCLC have undergone examination, including 20 men and 5 women aged between 50–75 years (average age 62.6±6.1 years). 24 healthy individuals including 18 men and 6 women aged between 49–71 years (average age 59.5±6.6 years) formed a control group. In cancer patients the concentration of vitamins A, C and E was assessed by spectrophotometry using T60V spectrophotometer (PG Instruments) before and after first-line chemotherapy, while in control group it was assessed only once.
Results
. The concentration of A, C and E vitamins in plasma of NSCLC patients was lower (p < 0.05) than in the control group. After 6 weeks of chemotherapy another significant drop in vitamin concentrations in NSCLC patients was observed (p < 0.05) and was biggest for vitamin C (39.1%).
Conclusions
. Lowering of A, C and E vitamins concentrations in the plasma of NSCLC patients suggests a weakening of antioxidative barrier. Chemotherapy leads to further fall in the concentration of those vitamins in patients’ plasma.

Key words: lung cancer, chemotherapy, reactive oxygen species, antioxidative vitamins

Pol. Merk. Lek., 2013, XXXV, 205, 18