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Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/3: 125-130 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/3: 125-130

Title: Urinary tract infections and uropathogens’ antibiotic susceptibility in patients hospitalized in internal medicine clinic

Authors: Krakowska-Stasiak M., Polanowska I., Kucia A., Grys I., Witkowska B.

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03-03-2014

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN ENGLISH.

Urinary tract infections and uropathogens’ antibiotic susceptibility in patients hospitalized in internal medicine clinic

Krakowska-Stasiak M.1, Polanowska I.2, Kucia A.1, Grys I.1, Witkowska B.2


5th Military Hospital in Krakow, Poland: 1Department of Internal Medicine; 2Medical Analytics Institution, Microbiological Laboratory

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014; Vol. 20, No. 3, 125

The aim of the study was to determine the antibiotic susceptibility of uropathogens isolated from patients hospitalized in the Internal Medicine Clinic of 5th Military Hospital in Krakow in the year 2013.
Material and methods
. A total of 234 urine culture were taken from patients hospitalized in the Internal Medicine Clinic in the year 2013. Patients’ demographical data, urine culture results, microorganisms’ susceptibility to antibiotics and resistance rates to antimicrobial agents were collected in Microsoft Excel, then transferred into PQStat ver 1.4.2.324. for statistical analysis. Fisher’s test was used to analyze the parameters. A p value of < 0,05 was considered statistically significant, and p value of < 0,01 was considered high statistically significant.
Results
. From all urine cultures taken from patients in our Clinic 49,14% were positive for bacterial growth with highest prevalence of E. coli (52,17%) followed by Klebsiella spp (16,52%), Proteus spp (10,43%), Pseudomonas spp (6,96%), Enterobacter spp (4,34%) and Staphylococcus spp (2,61%). 18,2% isolates were found to produce ESBL (Extendedspectrum beta-lactamase). Our E.coli isolates showed high percent susceptibility to amikacin (100%), ertapenem (100%), meropenem (100%), cefotaxime (100%), ceftazidime (100%), followed by cefuroxime axetil (98%), gentamicin (96,1%), amoxicillin/ clavulanic acid (86,3%) and nitrofurantoin (84,3%). Moreover, this study concludes that E. coli and other isolates were more sensitive to aminoglycosides, cephalosporins of 3rd generation and carbapenems in comparison to the other antibiotics tested and, therefore, these drugs may be considered for the treatment of UTIs in hospitalized patients in our region.
Conclusions
. The increasing rate of uropathogens’ resistance to traditional empiric antibiotics has an important effect on the empiric selection of antimicrobials. We recommend that the constant evaluation of the antibiotic sensitivity pattern of UTI pathogens in a particular environment should be carried out.

Key words: urinary tract infection, antibiotic, uropathogen