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Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/3: 140-144 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/3: 140-144

Title: Necrotizing soft tissue infection during leflunomide treatment

Authors: Paluchowska E., Wiśniewska N., Owczarek W., Sadowski J., Gołębiowski G.

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06-03-2014

40,00 zł

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Necrotizing soft tissue infection during leflunomide treatment

Paluchowska E.1, Wiśniewska N.1, Owczarek W.1, Sadowski J.2, Gołębiowski G.2


Military Institute of Medicine in Warsaw, Poland, Central Clinical Hospital of the Ministry of National Defense: 1Department of Dermatology; 2Department of Traumatology, Orthopaedics Department of Infection Locomotor System

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014; Vol. 20, No. 3, 140

Necrotizing soft tissue infections (NSTI) is a rare but highly lethal group of infections on the multiple layers of soft tissue. It may be a consequence of surgery, severe trauma, in patients with cardiovascular disorders, diabetes or rarely treated with immunosuppressive drugs. Leflunomide is an immunomodulatory and immunosuppressive drug used in patients with rheumatoid arthritis. The paper presents a case of a 58-year old woman with necrotizing soft tissue infection of the buttock during the therapy of rheumatoid arthritis with leflunomide (Arava). The aim of the study was to draw attention to the possibility of severe infection – necrotic tissue infection in patients treated with immunosuppressive therapy and a discussion on possible diagnostic and therapeutic methods.

Key words: necrotizing soft tissue infection, rheumatoid arthritis, leflunomide, debridement