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Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXII/191: 302-305 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXII/191: 302-305

Title: Albuminuria in patients with type 2 diabetes mellitus in relation to percentage of HbA1c

Authors: Kamińska J., Koper O.M., Czyżewska J., Wasilewska K., Kemona H.

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Albuminuria in patients with type 2 diabetes mellitus in relation to percentage of HbA1c


Kamińska J.1, Koper O.M.1, Czyżewska J.1, Wasilewska K.2, Kemona H.1

1Department of Clinical Laboratory Diagnostics, Medical University of Białystok, Poland; 2Clinical Department of Internal Diseases Endocrinology and Diabetology, Provincial Hospital J. Śniadeckiego of Białystok

Albuminuria is an early marker of the microvascular and macrovascular complications in patients with type 2 diabetes mellitus. Metabolic complication accompanying the disease, especially hyperglicaemia, have significant influence on the range of albumin excretion.
The aim of the study
was to evaluate urinary albumin excretion and percentage of glycated hemoglobin (HbA1c), in relation to fasting and postprandial glycaemia.
Material and methods
: Research was made in two groups of patients with confirmed albuminuria: in the 1st group with good glycemic control with HbA1c 6,1%-<=6,5%, and in the 2-nd group with poor glycemic control with HbA1c >6,5%–<=10%. The control group consisted of 21 patients with essential hypertension and coexisted albuminuria, not suffering from diabetes. The average fasting and postprandial glycemic were calculated for each patient on the basis of the last three values of glycaemia from the patient’s self-control test. The extent of albuminuria and the percentage of HbA1c were determined by the immunoturbidimetric test.
Results
. The highest albumin excretion in urine was noticed in the group with poor glycemic control, a slightly lower level of albuminuria was found in the group with good glycemic control, however the lowest level of albumin excretion was noticed in the control group. The differences were not statistically significant. The fasting glycaemia as well as postprandial glycaemia were increased in the group with higher percentage of HbA1c (p
Conclusions. The excretion of albumin in urine rises with increased glycaemia and percentage of glycosylated hemoglobin. Fasting glycaemia as well as postprandial glycaemia have influence on the percentage of glycated hemoglobin.

Key words: albuminuria, type 2 diabetes mellitus, glycated hemoglobin (HbA1c)

Pol. Merk. Lek., 2012, XXXII, 191, 302