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Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXII/191: 313-317 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXII/191: 313-317

Title: Usefulness of creatinine and cystatin C in the assessment of renal function in chronic kidney disease and coexisting diseases

Authors: Niemczyk S., Piotrowska M., Szamotulska K.

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Usefulness of creatinine and cystatin C in the assessment of renal function in chronic kidney disease and coexisting diseases


Niemczyk S.1, Piotrowska M.2, Szamotulska K.3

1Military Institute of Medicine in Warsaw, Poland, Department of Internal Diseases, Nephrology and Dializotherapy, Central Clinical Hospital of the Ministry of National Defense; 2Institute of Cardiology in Warsaw, Poland, Department of Heart Insufficiency and Transplantology; 3Institute of Mather and Child in Warsaw, Poland, Department of Epidemiology

The authors present literature review of usefulness of serum creatinine concentration measurements in comparison with cystatin C concentration for assessment renal function in chronic kidney disease and concomitant diseases. In this article different methods of determining renal filtration are critically discussed. In comparison with creatinine, cystatin C is a good parameter for assessing stable renal function and their early damage. It is a marker of subclinical disorders in chronic renal failure which is also useful in assessing renal dysfunction in coexisting diseases. Cystatin C is more precise than creatinine especially in pediatric, elderly, diabetic and oncological patients. It is more accurate because it is not associated with amount of muscle mass and nutritional status. Among many parameters cystatin C is a promising marker broadening diagnostic tools in nephrology.

Key words: cystatin C, creatinine, glomerular filtration rate, chronic kidney disease, coexisting diseases, diabetes mellitus

Pol. Merk. Lek., 2012, XXXII, 191, 313