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Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXII/191: 318-322 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXII/191: 318-322

Title: Biologic therapy and new therapeutic opportunities in systemic lupus erythematosus

Authors: Gumkowska O., Kotyla P.J., Kucharz E.J.

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Biologic therapy and new therapeutic opportunities in systemic lupus erythematosus


Gumkowska O., Kotyla P.J., Kucharz E.J.

Department of Internal Diseases and Rheumatology, Silesian Medical University of Katowice, SPSK nr 7 GCM

Systemic lupus erythematosus is a connective tissue disease of unknown origin and unpredictable course. At the moment there is no specific targeted treatment for the disease and corticosteroids are still main therapeutic option. Steroid use, however brings many side effects. Therefore searching for new treatment strategies is at the moment the main challenge for rheumatologists. The potential targets for the treatment include B and T cells co-stimulation molecules and various cytokines. In the paper potential targets for treatment of SLE have been reviewed with the special emphasis to the result of recently finished clinical trials in this indication.

Key words: systemic lupus erythematosus, biologics, anticytokine therapy, B-cell depletion, regulatory T cells

Pol. Merk. Lek., 2012, XXXII, 191, 318