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Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXII/190: 250-255 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXII/190: 250-255

Title: Molecular aspects of allergy to plant products. Part III. Panallergens and breeding of hypoallergenic cultivars

Authors: Bokszczanin K.Ł., Przybyła A.A.

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Molecular aspects of allergy to plant products. Part III. Panallergens and breeding of hypoallergenic cultivars


Bokszczanin K.Ł.1, Przybyła A.A.2

University of Life Sciences (WULS) in Warsaw, Poland, Faculty of Horticulture and Landscape Architecture: 1Department of Plant Genetics, Breeding and Biotechnology; 2Department of Pomology

In addition to major allergens, also minor allergens, i.e. panallergens have been shown to be responsible for many IgE cross-reactions even between unrelated pollen and plant food allergen sources. It can be explained also by cross-allergenicity underlying the T cell response to conserved regions of panallergens. In this article, we focus on known panallergens which presently comprise a few protein families, including non-specific lipid transfer proteins (nsLTP) (PR-14), thaumatin like proteins (TLP) (PR-5), profilins, and polcalcins. Food allergy has an impact on the quality of life of an allergic patient. The way of developing novel plant cultivars with decreased allergenicity and possibility of down-regulating the expression of an allergen by genetic modification are discussed.

Key words: panallergens, PR-5 proteins, PR-14 proteins, profilins, polcalcins, breeding of hypoallergenic cultivars

Pol. Merk. Lek., 2012, XXXII, 190, 250