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Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXII/190: 270-273 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2012, XXXII/190: 270-273

Title: The laboratory diagnostics of alcoholic disease

Authors: Strumnik A., Karski J.

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

The laboratory diagnostics of alcoholic disease


Strumnik A., Karski J.

Non-public Health Care Facility “Clinic” Hospital in Ryki, Poland

Ethyl alcohol is metabolized in the body with the involvement of three metabolic pathways which are the system of alcohol dehydrogenase (ADH), the layout of the microsomal oxidation of alcohol (MEOS) and pathway of catalase. The above-mentioned routes are oxidative mechanisms for the elimination of alcohol and run in the liver. For the mechanism of oxidative metabolites of alcohol elimination include sialic acid, β-hexosaminidase, carbohydrate-deficient transferrin, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, and 5-hydroxytryptophol. Minor importance in the detoxification pathway of alcohol nonoxidative whose metabolites act as indicators of recent alcohol consumption. These include fatty acid ethyl esters, ethyl glucuronide, etyl sulphate and phosphatidylo ethanol.

Key words: ethanol, markers of ethanol abuse

Pol. Merk. Lek., 2012, XXXII, 190, 270