Pol. Merkur. Lek (Pol. Med. J.), 2011, XXXI/185: 274-277 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2011, XXXI/185: 274-277

Title: Respiratory functional impairment in patients with liver cirrhosis

Authors: Siemieniako A., Pogorzelska J., Łapiński T.W., Flisiak R.

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Respiratory functional impairment in patients with liver cirrhosis

Siemieniako A.1, Pogorzelska J.2, Łapiński T.W.2, Flisiak R.2

1Regional Combined Hospital in Białystok, Poland, Department of Anesthesiology and Intensive Care; 2Medical University of Białystok, Poland, Department of Infectious Diseases and Hepatology

End stage of liver disease can cause the respiratory tract dysfunction. Early diagnosis of hepatopulmonary syndrome can affect the therapy and determine the timing and risks of orthotopic liver transplantation.
The aim of the study
was to determine the respiratory distress in relation to liver damage assessed with scoring scales of Child-Pugh, MELD, GAHS, as well as fibrinogen and albumin levels.
Material and methods
. Respiratory disorders were diagnosed by spirometry and plethysmography. The study included 71 patients with alcoholic liver cirrhosis. The results obtained were analyzed using the nonparametric Spearman correlation test and U-Mann-Whitney test.
. Analysis showed that the severity of liver damage leads to significant deterioration in DLCO/VA, (Child-Pugh: r = -0.22; p < 0.04; the concentration of albumin: r = -0.24; p < 0.03). Depending on the scale GAHS correlation between the severity of liver failure and the deterioration rate Tiffeneau (FEV1/VC; r = -0.30; p < 0.004), reduction in TGV (r = -0.39; p < 0. 0004), TLC (r = -0.27; p < 0.01) and RV (r = -0.31; p < 0.004) has been observed.
. Among patients with liver cirrhosis there are mainly restrictive pulmonary disorders and the difficulty of gas diffusion in the alveoli. These disorders correlate with the severity of liver damage assessed with Child-Pugh or GAHS classifications and albumin concentration.

Key words: alcoholic liver cirrhosis, spirometry, plethysmography

Pol. Merk. Lek., 2011, XXXI, 185, 274