Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/2: 082-086 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/2: 082-086

Title: In vitro allergy diagnostics

/ Authors: Skotny A., Kmiecik B., Siwak E., Mędrala W.

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In vitro allergy diagnostics

Skotny A.1, Kmiecik B.2, Siwak E.1, Mędrala W.1

1Medical University of Wrocław, Poland, Chair and Department of Internal Diseases, Geriatry and Allergology; 2Politechnic University of Wrocław, Poland

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014; Vol. 20, No. 2, 82

Allergic diseases appear to be a major problem by tapping the growing percentage of the population. Given that every year we see an increase in the incidence of various forms of hypersensitivity. It should strive to improve not only the ways to patients' treatment, but primarily to allergies diagnostics. Currently available diagnostic is sometimes ambiguous and incomplete. It boils down to carry out a detailed clinical history and link it with the results of taken tests (mostly skin tests and determination of specific IgE). However, there are situations in which the in vivo studies (often used skin tests and drug provocation) can lead to various complications (up to anaphylactic shock) that can be threat to the life and health of patients. Therefore, a necessary and very important is the use and development of in vitro diagnostic methods. This paper includes description of the most common and performed in vitro diagnostic tests: determination of total IgE, specific IgE, histamine release tests, production of leukotriene C4-CASTA-ELISA test, evaluation of intracellular cytokine production test or basophil activation tests. It should be emphasized that there are many excellent diagnostic methods present in the market, although it is still worth pursuing for their improvement and optimization.

Key words: allergy, diagnostics, hypersensitivity