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Int. Rev. Allergol. Clin. Immunol. Family Med., 2015, XXI/2: 055-061 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2015, XXI/2: 055-061

Title: Receptors for Fc region of immunoglobulin G in the etiopathogenesis of autoimmunological diseases 

Authors: Nowakowski S, Typiak M, Dubaniewicz A.

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01-02-2015

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Receptors for Fc region of immunoglobulin G in the etiopathogenesis of autoimmunological diseases


Nowakowski S1, Typiak M2, Dubaniewicz A2.

Medical University of Gdańsk, Poland: 1Clinic of Internal Medicine, Connective Tissue Diseases, and Geriatrics; 2Department of Pulmonology

Int. Rev. Allergol. Clin. Immunol. Family Med., 2015; Vol. 21, No. 2, 55

Receptors for Fc region of immunoglobulin G (FcγR) play a significant role in the immune response, as they connect the humoral and cellular components of the immunity. They are essential for the immune complexes clereance, (auto)antigen presentation, phagocytosis, antibody-depended cell-mediated cytotoxicity, regulation of cytokines and hydroxyl-radicals production. A link has been established between some FCGRs' genes polymorphisms and susceptibility to many autoimmune disorders, including systemic lupus erythromatosus, rheumatoid arthritis as well as to sarcoidosis. More studies of FcγR will undoubtedly help us to understand the pathogenesis of the autoimmunity and they may reason for looking for a way to a new, more successful, treatment of these diseases.

Key words: FcγR receptor, autoimmunity, autoimmunological diseases, sarcoidosis