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Int. Rev. Allergol. Clin. Immunol. Family Med., 2015, XXI/2: 068-072 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2015, XXI/2: 068-072

Title: The negative influence of allergy on idiopathic nephrotic syndrome in children – preliminary report

Authors: Kuźma-Mroczkowska E, Pańczyk-Tomaszewska M, Roszkowska-Blaim M. 

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03-02-2015

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

The negative influence of allergy on idiopathic nephrotic syndrome in children – preliminary report


Kuźma-Mroczkowska E, Pańczyk-Tomaszewska M, Roszkowska-Blaim M.

Chair and Department of Pediatry and Nephrology of Medical University of Warsaw, Poland

Int. Rev. Allergol. Clin. Immunol. Family Med., 2015; Vol. 21, No. 2, 68

The aim of the study was to assess the influence of allergy on the course of idiopathic nephrotic syndrome (INS) in children.
Material and methods
. The study was performed in 19 children (9 girls and 10 boys) aged 4.8±2.6 years with the first bount of nephrotic syndrome. Before starting of glucocorticosteroids (GCS) treatment in all patients medical history of allergy was evaluated and serum level of IgE (IgE) and specific IgE (sIgE) for 20 food and 20 inhalled allergens were measured. During 12 months observation, time of maintain proteinuria, number of relapses and days without GCS were analyzed.
Results
. Positive allergic history was found in 9 children (47.4%): allergic dermatitis in 3, recurrent obstructive bronchitis in 3, skin rash in 2, asthma in 1 child. Serum level of IgE was elevated in 8 children (from 17 to 493 KU/L, median 53.9 KU/L;). Elevated serum level of sIgE was observed in 10 (53%) children. Time of maintain proteinuria was 9±3.14 days, number of relapses 2.04±1.67/patient/year. In children with elevated serum level of IgE in compare to children with normal serum level of IgE the higher number of relapses was observed (2.62±1.18 vs 1.36±1.56, p=0.073). Number the days without GCS was from 0 to 212 median 45. Possitive correlation between elevated serum level of IgE and number of INS relapses during one year observation was found (R= 0.42 p=0.013) and negative between positive allergic history and number of the days without GCS (R= -0.37, p=0.026).
Conclusion
. Allergy predisposes to recurrences of proteinuria in patients with INS.

Key words: IgE, nephrotic syndrome, children, allergy