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Int. Rev. Allergol. Clin. Immunol. Family Med., 2015, XXI/2: 077-085 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2015, XXI/2: 077-085

Title: Clinical and therapeutic implications of asthma and chronic obstructive pulmonary disease overlap syndrome 

Authors: Chudzicka A, Płusa T.

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05-02-2015

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

Clinical and therapeutic implications of asthma and chronic obstructive pulmonary disease overlap syndrome


Chudzicka A, Płusa T.

Military Institute of Medicine in Warsaw, Poland, Central Clinical Hospital of the Ministra of National Defense, Departament of Internal Medicine, Pneumonology and Allergology

Int. Rev. Allergol. Clin. Immunol. Family Med., 2015; Vol. 21, No. 2, 77

Asthma and chronic obstructive pulmonary disease (COPD) are two of the most common airway diseases. So far, they were considered as two separate diseases. Recently, the fact, that they may coexist, is underlined, which was called asthma-COPD overlap syndrome. The part of the risk factors are common for both diseases. The definition of the overlap syndrome is controversial. Further investigations on airway remodeling and inflammatory processes may help to determine the diagnostic criteria. New mediators are searched, which expression is characteristic for this syndrome. The differentiation of clinical outcome in patients with overlap syndrome compared with patients with either asthma or COPD is underlined. Perhaps the overlap syndrome should be considered as a new COPD phenotype. In addition to clinical differences also the treatment of patients with overlap syndrome should be more tailored individually, because these patients response better to glucocorticoids than the other group of patients with COPD. Similarly, in these patients is improved clinical results in the application of the newly introduced products which are LABA (long-acting beta agonists), and LAMA (long-acting anti-muscrinic antagonist).

Key words: asthma, COPD, overlap syndrome Choroby obturacyjne