Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/1: 048-052 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014, XX/1: 048-052

Title: The circadian rhythm of COPD symptoms

/ Authors: Płusa T.

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The circadian rhythm of COPD symptoms

Płusa T.

Military Institute of Medicine in Warsaw, Poland, Central Clinical Hospital of the Ministry of National Defense, Department of Internal Medicine, Pneumonology and Allergology

Int. Rev. Allergol. Clin. Immunol. Family Med., 2014; Vol. 20, No. 1, 048

Typical symptoms of COPD are dyspnea at rest and exercise, chronic cough and sputum production of large amounts, as well as the other symptoms. The circadian rhythm of work of internal organs, including the respiratory tract, has been known as a mechanism involved in the optimization of their function. In COPD patients a decrease of spirometry values was observed at night. It was also shown that the restriction of air flow in the bronchi of patients with COPD is not correlated with reported symptoms, the degree of impairment of mobility and quality of life. Following the saturation abnormalities in these patients was proposed division – desaturators and nondesaturators. Underlying these changes may be disturbances of circadian rhythm of corticosterone and serotonin secretion. Knowledge of circadian rhythm in a patient with symptoms of COPD should be considered as a basis for the selection of the individual treatment. Particularly useful seem to be the latest generation of drugs, such as combined preparations of indacaterol and glycopyronium that its action covers the entire day, giving the opportunity to improve the quality of life.

Key words: COPD, symptoms, circadian rhythm