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Int. Rev. Allergol. Clin. Immunol. Family Med., 2016, XXII/1: 028-033 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2016, XXII/1: 028-033

Title: The efficacy and safety of topical therapy with diphenylcyclopropenone in the treatment of alopecia areata – a retrospective study 

Authors: Borowska K, Wasyłyszyn T, Zabielski S.

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04-01-2016

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN ENGLISH.

The efficacy and safety of topical therapy with diphenylcyclopropenone in the treatment of alopecia areata – a retrospective study

Borowska K1,2, Wasyłyszyn T3, Zabielski S4.
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1Medical Center CADERM, Warsaw, Poland; 2Department of Histology and Embryology with Experimental Cytology Unit, Medical University of Lublin, Poland; 3Medical Center Gabinet Dermatologiczny Tomasz Wasyłyszyn, Warsaw, Poland; 4School of Economics, Law and Medical Sciences in Kielce, Poland

Int Rev Allergol Clin Immunol Family Med, 2016; Vol. 22, No. 1, 028

Alopecia areata (AA) is an autoimmune disease involving hair follicles characterized by hair loss. It is considered that diphenylcyclopropenone (DCP) is one of the effective modalities for the treatment of AA through induction of an allergic contact dermatitis.
The aim of
our study was to evaluate the efficacy and safety of DCP in the treatment of AA. We retrospectively analyzed 100 patients with AA treated with topical applications of DCP between March 2009 and October 2013.
Material and methods
. The patients were grouped into one of the six categories according to a disease progress. The cosmetically acceptable regrowth was observed in 80% patients during two years of observation.
Results
. Effect of the treatment was observed in 94 patients. Positive effect was observed in 91 patients (91%). The worsening was observed in 3 patients (3%). The complete lack of response was observed in 6 patients (six patients were anergic to DCP). The side effects observed were moderate, they were well tolerated and none of the patients ended the treatment because of them.
Conclusions
. This retrospective case series shows that the topical therapy with DCP of patients with AA is effective and generally well tolerated.

Key words: alopecia areata, diphenylcyclopropenone, DCP