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Int. Rev. Allergol. Clin. Immunol. Family Med., 2016, XXII/1: 039-043 Maximize

Int. Rev. Allergol. Clin. Immunol. Family Med., 2016, XXII/1: 039-043

Title: Toxicity, cytotoxicity and genotoxicity of 4 polyamidoamine (PAMAM) dendrimers used as drug and drug carries 

Authors: Borowska K. 

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06-01-2016

40,00 zł

SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN ENGLISH.

Toxicity, cytotoxicity and genotoxicity of 4 polyamidoamine (PAMAM) dendrimers used as drug and drug carries

Borowska K1,2.

1Medical University of Lublin, Department of Histology and Embryology with Experimental Cytology Unit, Lublin, Poland; 2Medical Center CADERM, Warsaw, Poland

Int Rev Allergol Clin Immunol Family Med, 2016; Vol. 22, No. 1, 039

Dendrimers are hyperbranched, monodisperse, three-dimensional macromolecules with defined molecular weight and host-guest entrapment properties. Polyamidoamine (PAMAM) dendrimers have been widely used as drug, drug carriers and non-viral gene vectors. The promising results from in vitro and vivo studies open up the possibility of PAMAM dendrimers being applied as a new generation of nano-therapeutic agents. Nanotechnology plays a unique instrumental role in the revolutionary development of drug and drug delivery. This paper will review the toxicity, cytotoxicity and genotoxicity of 4 polyamidoamine (PAMAM) dendrimer (PAMAM G4). PAMAM dendrimers generation 4 which hold great promises for medicine but yet information regarding their toxicity, cytotoxicity and genotoxicity is incomplete.

Key words: PAMAM G4 dendrimers, toxicity, cytotoxicity, genotoxicity