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Pol. Merkur. Lek (Pol. Med. J.), 2016, XLI/241: 011-015 Maximize

Pol. Merkur. Lek (Pol. Med. J.), 2016, XLI/241: 011-015

Title: The impact of the dosing, a 12-week physical training on the concentration of NT-proBNP and D-Dimer in patients with heart failure and impaired functional capacity in VII–X decade of life 

Authors: Andrzejczak-Karbowska M, Irzmański R.

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SUMMARY IN POLISH & ENGLISH. FULL ARTICLE ONLY IN POLISH.

The impact of the dosing, a 12-week physical training on the concentration of NT-proBNP and D-Dimer in patients with heart failure and impaired functional capacity in VII–X decade of life


Andrzejczak-Karbowska M, Irzmański R.

Department of Internal Medicine and Cardiological Rehabilitation, Medical University of Lodz, Poland

Chronic heart failure (CHF), despite the preventive measures taken is the most common problem of modern cardiology. The aging of the body predisposes to the development of PNS, because qualitative changes taking place in the heart of the patient in the elderly are similar to those occurring among patients with heart failure. A growing problem of eldery patients becomes a deterioration of physical fitness leading to the reduction of activity and sedentary lifestyle. There is no doubt that increasing physical activity in the elderly should aim not only to restore the patient to a previous level of functioning, but also improve their physical resources to a higher level of efficiency and to facilitate independent functioning in everyday life.
The aim of the study
was to analyze the assessment of 12-week controlled physical training on the concentration of NT-proBNP and D-Dimer in patients with heart failure and impaired functional capacity in VII–X decade of life.
Materials and methods
. The study included a group of 72 patients, elderly men and women (within a mean age of 81,6 ± 6,4) with stable heart failure. The plasma concentration of B-type natriuretic peptide and D-Dimer was measured in each and every subject. The subjects were also asked to perform a Timed Up and Go Test (TUG) and the normal gait speed was analyzed over a 6 meter distance.
Results
. 12-weeks cardiac rehabilitation process, improved the functional capacity of patients which is proved by reduction in duration of the TUG. Analysis of the results showed a correlation between the results of the test TUG and speed of gait. In the group of patients who underwent rehabilitation, a decrease in the concentration of plasma NT-proBNP and D-Dimer were observed.
Conclusions
. The low-intensity physical training increases functional capacity which is shown to shorten the duration of the TUG test and affects the modulation of neuroendocrine and concentration of NT-proBNP in patients with CHF, regardless of gender.

Key words: chronic heart failure (CHF), NT-proBNP, D-Dimer, physical activity, aging

Pol Med J, 2016; XLI (241); 11–15